ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of macrophage colony-stimulating factor (MCSF) in the pathogenesis of preeclampsia.</p><p><b>METHODS</b>By ELISA method, MCSF concentrations were determined in serum samples obtained from 39 patients with preeclampsia and 40 normal pregnant women as controls. The concentrations of serum MCSF were compared between preeclampsia and normal pregnancy, and between early-onset and late-onset preeclampsia.</p><p><b>RESULT</b>Serum MCSF concentrations were significantly higher in preeclamptic women than those in controls (431.0 kIU compared with 179.1 kIU, P<0.001). There were no significant differences in serum MCSF levels between early-onset and late-onset preeclampsia (P>0.05). Serum MCSF was not correlated with maternal age, gestational age, and placenta weight (P>0.05 for all).</p><p><b>CONCLUSION</b>Increased level of serum MCSF is an important indicator of preeclampsia and it may play a role in the pathogenesis of the disease.</p>
Subject(s)
Adult , Female , Humans , Pregnancy , Macrophage Colony-Stimulating Factor , Blood , Pre-Eclampsia , BloodABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of interleukin (IL)-18 concentrations in serum and placenta and preeclampsia.</p><p><b>METHODS</b>Twenty-seven patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placenta samples were taken and serum and placental IL-18 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared.</p><p><b>RESULT</b>(1) The median of serum IL-18 in patients with preeclampsia was 704 ng/L, which was significantly higher than that of control group (470 ng/L, P<0.05). (2) The median of placental IL-18 in patients with preeclampsia was 105 ng/L, which was also significantly higher than that of control group (31.5 ng/L, P<0.005).</p><p><b>CONCLUSION</b>Increased serum and placental levels of IL-18 were presented in preeclampsia as compared to normal pregnancy, which might offer insight into the pathogenesis of the disease.</p>